diff --git a/.chloggen/ha-webhook.yaml b/.chloggen/ha-webhook.yaml
new file mode 100644
index 0000000000..33ec4787cb
--- /dev/null
+++ b/.chloggen/ha-webhook.yaml
@@ -0,0 +1,18 @@
+# One of 'breaking', 'deprecation', 'new_component', 'enhancement', 'bug_fix'
+change_type: enhancement
+
+# The name of the component, or a single word describing the area of concern, (e.g. collector, target allocator, auto-instrumentation, opamp, github action)
+component: auto-instrumentation
+
+# A brief description of the change. Surround your text with quotes ("") if it needs to start with a backtick (`).
+note: Provide high availability for the instrumentation webhook on OpenShift.
+
+# One or more tracking issues related to the change
+issues: [5010]
+
+# (Optional) One or more lines of additional information to render under the primary note.
+# These lines will be padded with 2 spaces and then inserted directly into the document.
+# Use pipe (|) for multiline entries.
+subtext: |
+  On OpenShift, the operator is deployed with 2 replicas. This ensures the auto-instrumentation pod mutating webhook
+  high availability. The operator deployment now also defines PodDisruptionBudgets to ensure the replicas run on different nodes.
diff --git a/bundle/community/manifests/opentelemetry-operator.clusterserviceversion.yaml b/bundle/community/manifests/opentelemetry-operator.clusterserviceversion.yaml
index 29ef4b9305..3ea11d67ce 100644
--- a/bundle/community/manifests/opentelemetry-operator.clusterserviceversion.yaml
+++ b/bundle/community/manifests/opentelemetry-operator.clusterserviceversion.yaml
@@ -99,7 +99,7 @@ metadata:
     categories: Logging & Tracing,Monitoring,Observability
     certified: "false"
     containerImage: ghcr.io/open-telemetry/opentelemetry-operator/opentelemetry-operator
-    createdAt: "2026-04-27T14:53:29Z"
+    createdAt: "2026-04-29T13:09:32Z"
     description: Provides the OpenTelemetry components, including the Collector
     operators.operatorframework.io/builder: operator-sdk-v1.29.0
     operators.operatorframework.io/project_layout: go.kubebuilder.io/v3
diff --git a/bundle/openshift/manifests/opentelemetry-operator-controller-manager_policy_v1_poddisruptionbudget.yaml b/bundle/openshift/manifests/opentelemetry-operator-controller-manager_policy_v1_poddisruptionbudget.yaml
new file mode 100644
index 0000000000..b6335d0164
--- /dev/null
+++ b/bundle/openshift/manifests/opentelemetry-operator-controller-manager_policy_v1_poddisruptionbudget.yaml
@@ -0,0 +1,13 @@
+apiVersion: policy/v1
+kind: PodDisruptionBudget
+metadata:
+  labels:
+    app.kubernetes.io/name: opentelemetry-operator
+    control-plane: controller-manager
+  name: opentelemetry-operator-controller-manager
+spec:
+  minAvailable: 1
+  selector:
+    matchLabels:
+      app.kubernetes.io/name: opentelemetry-operator
+      control-plane: controller-manager
diff --git a/bundle/openshift/manifests/opentelemetry-operator.clusterserviceversion.yaml b/bundle/openshift/manifests/opentelemetry-operator.clusterserviceversion.yaml
index 3996aaf428..f1068d41e7 100644
--- a/bundle/openshift/manifests/opentelemetry-operator.clusterserviceversion.yaml
+++ b/bundle/openshift/manifests/opentelemetry-operator.clusterserviceversion.yaml
@@ -99,7 +99,7 @@ metadata:
     categories: Logging & Tracing,Monitoring,Observability
     certified: "false"
     containerImage: ghcr.io/open-telemetry/opentelemetry-operator/opentelemetry-operator
-    createdAt: "2026-04-27T14:53:29Z"
+    createdAt: "2026-04-29T13:09:32Z"
     description: Provides the OpenTelemetry components, including the Collector
     operators.operatorframework.io/builder: operator-sdk-v1.29.0
     operators.operatorframework.io/project_layout: go.kubebuilder.io/v3
@@ -540,18 +540,32 @@ spec:
           control-plane: controller-manager
         name: opentelemetry-operator-controller-manager
         spec:
-          replicas: 1
+          replicas: 2
           selector:
             matchLabels:
               app.kubernetes.io/name: opentelemetry-operator
               control-plane: controller-manager
-          strategy: {}
+          strategy:
+            rollingUpdate:
+              maxSurge: 1
+              maxUnavailable: 1
+            type: RollingUpdate
           template:
             metadata:
               labels:
                 app.kubernetes.io/name: opentelemetry-operator
                 control-plane: controller-manager
             spec:
+              affinity:
+                podAntiAffinity:
+                  preferredDuringSchedulingIgnoredDuringExecution:
+                  - podAffinityTerm:
+                      labelSelector:
+                        matchLabels:
+                          app.kubernetes.io/name: opentelemetry-operator
+                          control-plane: controller-manager
+                      topologyKey: kubernetes.io/hostname
+                    weight: 100
               containers:
               - args:
                 - --zap-log-level=info
diff --git a/config/overlays/openshift/kustomization.yaml b/config/overlays/openshift/kustomization.yaml
index 47d7cd1e4a..06b534510b 100644
--- a/config/overlays/openshift/kustomization.yaml
+++ b/config/overlays/openshift/kustomization.yaml
@@ -1,5 +1,6 @@
 resources:
 - ../../default
+- pdb.yaml
 
 patches:
 - path: manager-patch.yaml
diff --git a/config/overlays/openshift/manager-patch.yaml b/config/overlays/openshift/manager-patch.yaml
index aa14a7a62b..2e7ac528de 100644
--- a/config/overlays/openshift/manager-patch.yaml
+++ b/config/overlays/openshift/manager-patch.yaml
@@ -1,3 +1,25 @@
+- op: replace
+  path: "/spec/replicas"
+  value: 2
+- op: replace
+  path: "/spec/strategy"
+  value:
+    type: RollingUpdate
+    rollingUpdate:
+      maxUnavailable: 1
+      maxSurge: 1
+- op: add
+  path: "/spec/template/spec/affinity"
+  value:
+    podAntiAffinity:
+      preferredDuringSchedulingIgnoredDuringExecution:
+      - weight: 100
+        podAffinityTerm:
+          labelSelector:
+            matchLabels:
+              app.kubernetes.io/name: opentelemetry-operator
+              control-plane: controller-manager
+          topologyKey: kubernetes.io/hostname
 - op: add
   path: "/spec/template/spec/containers/0/args"
   value:
diff --git a/config/overlays/openshift/pdb.yaml b/config/overlays/openshift/pdb.yaml
new file mode 100644
index 0000000000..67af574045
--- /dev/null
+++ b/config/overlays/openshift/pdb.yaml
@@ -0,0 +1,14 @@
+apiVersion: policy/v1
+kind: PodDisruptionBudget
+metadata:
+  name: opentelemetry-operator-controller-manager
+  namespace: system
+  labels:
+    app.kubernetes.io/name: opentelemetry-operator
+    control-plane: controller-manager
+spec:
+  minAvailable: 1
+  selector:
+    matchLabels:
+      app.kubernetes.io/name: opentelemetry-operator
+      control-plane: controller-manager